Factor XI

Aliases:Plasma thromboplastin antecedent
Gene Symbol:F11
Type:serine protease
Main Action:Activates FIX
Genomic Reference Sequence:NG_008051.1
Locus Reference Genomic (LRG):LRG_583
Locus Specific Database (LSDB):https://dbs.eahad.org/
Amino Acid Numbering Conversion Factor (Old > New;+/-):18
Variant Details: Factor XI (1)
Predicted Mr (da):70,109
Predicted pl:8
Gene Size (bp):23,718
Transcript Size (nt):3,278
Number of Exons:15
Gene Location:4q35
Number of Amino Acids:625
Mature Protein:19-625
Observer Mr of Monomer (kDa):80*
Plasma Concentration (ug/ml):5
Plasma Molarity (nM):30
Half-life (h):45
cDNA Reference Sequence (NM):NM_000128.3
Protein Reference Sequence (NP):NP_000119.1
Reference cDNA Sequence +1ATG (fasta format):https://coagbase.org/wp-content/uploads/2022/01/NM_000128.fasta
Reference cDNA Sequence +1ATG (GenBank format):https://coagbase.org/wp-content/uploads/2022/01/NM_000128.gb
Reference cDNA Sequence +1ATG with translation and exons marked (pdf format):https://coagbase.org/wp-content/uploads/2022/01/NM_0001284_F11.pdf
*Factor XI circulates as a 160kDa homodimer of two 80kDa monomers