Fibrinogen (β chain)

Abbreviation:FGN
Aliases:FN
Gene Symbol:FGB
SubUnit:β
Type:insoluble polymer precursor
Main Action:Mechanical stabilisation of clot
Genomic Reference Sequence:NG_008833.1
Locus Reference Genomic (LRG):LRG_558
LOVD:https://www.LOVD.nl/FGB
Locus Specific Database (LSDB):https://site.geht.org/base-de-donnees-fibrinogene/
Amino Acid Numbering Conversion Factor (Old > New;+/-):
Variant Details: Fibrinogen (β chain) (1)
Predicted Mr (da):55,928
Predicted pl:9
Gene Size (bp):8,107
Transcript Size (nt):1,963
Number of Exons:8
Gene Location:4q28
Number of Amino Acids:491
Mature Protein:31-491
Observer Mr of Monomer (kDa):52***
Plasma Concentration (ug/ml):3000
Plasma Molarity (nM):9000
Half-life (h):90
cDNA Reference Sequence (NM):NM_005141.4
Protein Reference Sequence (NP):NP_005132.2
Reference cDNA Sequence +1ATG (fasta format):https://coagbase.org/wp-content/uploads/2022/01/NM_005141.fasta
Reference cDNA Sequence +1ATG (GenBank format):https://coagbase.org/wp-content/uploads/2022/01/NM_005141.gb
Reference cDNA Sequence +1ATG with translation and exons marked (pdf format):https://coagbase.org/wp-content/uploads/2022/01/NM_005141_FGB.pdf
***Fibrinogen circulates as a 340kDa complex of two each of A-, B- and C-chains