Abbreviation: | FGN |
Aliases: | FN |
Gene Symbol: | FGB |
SubUnit: | β |
Type: | insoluble polymer precursor |
Main Action: | Mechanical stabilisation of clot |
Genomic Reference Sequence: | NG_008833.1 |
Locus Reference Genomic (LRG): | LRG_558 |
LOVD: | https://www.LOVD.nl/FGB |
Locus Specific Database (LSDB): | https://site.geht.org/base-de-donnees-fibrinogene/ |
Amino Acid Numbering Conversion Factor (Old > New;+/-): |
Variant Details: Fibrinogen (β chain) (1)
Predicted Mr (da): | 55,928 |
Predicted pl: | 9 |
Gene Size (bp): | 8,107 |
Transcript Size (nt): | 1,963 |
Number of Exons: | 8 |
Gene Location: | 4q28 |
Number of Amino Acids: | 491 |
Mature Protein: | 31-491 |
Observer Mr of Monomer (kDa): | 52*** |
Plasma Concentration (ug/ml): | 3000 |
Plasma Molarity (nM): | 9000 |
Half-life (h): | 90 |
cDNA Reference Sequence (NM): | NM_005141.4 |
Protein Reference Sequence (NP): | NP_005132.2 |
Reference cDNA Sequence +1ATG (fasta format): | https://coagbase.org/wp-content/uploads/2022/01/NM_005141.fasta |
Reference cDNA Sequence +1ATG (GenBank format): | https://coagbase.org/wp-content/uploads/2022/01/NM_005141.gb |
Reference cDNA Sequence +1ATG with translation and exons marked (pdf format): | https://coagbase.org/wp-content/uploads/2022/01/NM_005141_FGB.pdf |
***Fibrinogen circulates as a 340kDa complex of two each of A-, B- and C-chains